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Basic and Clinical Neuroscience، جلد ۵، شماره ۳، صفحات ۱۸۲-۱۹۰
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| عنوان فارسی |
Microinfusion of Bupropion Inhibits Putative GABAergic Neuronal Activity of the Ventral Tegmental Area |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Microinfusion of Bupropion Inhibits Putative GABAergic Neuronal Activity of the Ventral Tegmental Area |
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| چکیده انگلیسی مقاله |
Introduction: The most common interpretation for the mechanisms of antidepression is the increase of the brain monoamine levels such as dopamine (DA). The increase of DA can reduce depression but it can also decrease the monoamine release because of autoreceptor inhibition. Although bupropion can decrease the dopamine release, there is evidence about stimulatory effects of chronic application of bupropion on ventral tegmental area (VTA) neurons. In this study, the intra-VTA acute microinfusion of bupropion on putative VTA non-Dopaminergic (VTA-nonDA) neuronal firing rates was evaluated by a single neuron recording technique. Methods: Animals were divided into 7 groups (sham, and 6 bupropion-microinfused groups with 1, 10-1, 10-2, 10-3, 10-4, and 10-5 mol, 1 &mul/3 min, intra-VTA). A single neuron recording technique was done according to the stereotaxic coordination. After 10 min baseline recording, ACSF or bupropion was microinfused. The recording continued to recovery period in the treated groups. The prestimulus time (PST) and interspike interval (ISI) histograms were calculated for every single unit. The assessment of the drug effect was carried out by one-way analysis of variance (ANOVA) and Post-hoc test. Results: 126 non-DA neurons were separated. Bupropion could inhibit 116 neurons and 11 neurons had no significant response. Maximum inhibition was 79.1% of baseline firing rate with 44.3 min duration. The inhibitory effect of bupropion was dose-dependent. Discussion: The acute inhibitory effects of bupropion on VTA-nonDA neurons can explain the fast inhibitory effects of bupropion and other antidepressants on the VTA. These data can explain some side effects of antidepressants. |
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| نویسندگان مقاله |
ساناز امیرآبادی | sanaz amirabadi
department of physiology, faculty of medicine, urmia university of medical sciences, urmia, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)
فیروز قادری پاکدل | firouz ghaderi pakdel
neurophysiology research center, urmia university of medical sciences, urmia, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)
پرویز شهابی | parviz shahabi
neuroscience research center, department of physiology, tabriz university of medical sciences, tabriz, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
سمیه نادری | somayyeh naderi
danesh pey hadi co., faculty of medicine, urmia university of medical sciences, urmia, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)
مصطفی ااشرفی اوصالو | mostafa ashrafi osalou
danesh pey hadi co., faculty of medicine, urmia university of medical sciences, urmia, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)
ulker cankurt | ulker cankurt
ulker cankurt
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-205&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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