|
|
Basic and Clinical Neuroscience، جلد ۵، شماره ۳، صفحات ۱۹۹-۲۰۴
|
|
|
| عنوان فارسی |
Effects of Hydro-alcoholic Extract of Anethum Graveolens Seed on Pentylenetetrazol-induced Seizure in Adult Male Mice |
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Effects of Hydro-alcoholic Extract of Anethum Graveolens Seed on Pentylenetetrazol-induced Seizure in Adult Male Mice |
|
| چکیده انگلیسی مقاله |
Introduction: Regarding chronic nature of epilepsy and its side effects and to access the effective treatment procedures, herbal medicine has received remarkable interest. The aim of this study was to determine the anticonvulsant effects of hydro-alcoholic extract of Anethum graveolens seed on pentylenetetrazol (PTZ) -induced seizure in male mice. Methods: Fifty-six albino male mice were divided randomly into seven groups including the negative control (saline), positive control (Phenobarbital) and treatment groups using different doses of hydro-alcoholic extract of Anethum graveolens seed (50, 100, 300, 500 and 1000 mg/ kg). To provoke convulsion, PTZ was injected to all groups and initiation time of myoclonic and tonic-clonic seizures as well as surveillance after 24 h were measured. Results: The results indicated that hydro-alcoholic extract of Anethum graveolens seed (AGS) delayed the initiation time of myoclonic and tonic-clonic seizures in comparison with saline group. The latency was considerable for myoclonic and tonic-clonic seizures at all above mentioned doses of AGS extract except for the lowest one. Moreover, the protective effect of AGS extract against mortality was statistically significant at all doses except for 50 mg/kg. Discussion: As the hydro-alcoholic extract of AGS showed an appropriate response in experimental model of convulsion, it might be considered as an adjuvant therapy with other traditional antiepileptic medications. |
|
| کلیدواژه‌های انگلیسی مقاله |
Anethum Graveolens,Pentylenetetrazol-induced,Seizure,Mice. |
|
| نویسندگان مقاله |
محمد رستم پور | mohammad rostampour
cellular and molecular research center, gilan university of medical sciences, rasht, iran ; department of physiology, gilan university of medical sciences, rasht, iran.
سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)
ارغوان غفاری | arghavan ghaffari
medical faculty of gilan university of medical sciences, rasht, iran.
سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)
پیمان صالحی | peyman salehi
shahid beheshti university, tehran, iran.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)
فرشید سعادت | farshid saadat
department of immunology, gilan university of medical sciences, rasht, iran.; cellular and molecular research center, gilan university of medical sciences, rasht, iran.
سازمان اصلی تایید شده: دانشگاه گیلان (Guilan university)
|
|
| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-207&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|