Basic and Clinical Neuroscience، جلد ۵، شماره ۳، صفحات ۲۳۱-۲۳۹
عنوان فارسی Propranolol–induced Impairment of Contextual Fear Memory Reconsolidation in Rats: A similar Effect on Weak and Strong Recent and Remote Memories
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عنوان انگلیسی Propranolol–induced Impairment of Contextual Fear Memory Reconsolidation in Rats: A Similar Effect on Weak and Strong Recent and Remote Memories
چکیده انگلیسی مقاله Introduction: Previous studies have demonstrated that the &beta-adrenergic receptor antagonist propranolol impairs fear memory reconsolidation in experimental animals. There are experimental parameters such as the age and the strength of memory that can interact with pharmacological manipulations of memory reconsolidation. In this study, we investigated the ability of the age and the strength of memory to influence the disrupting effects of propranolol on fear memory reconsolidation in rats. Methods: The rats were trained in a contextual fear conditioning using two (weak training) or five (strong training) footshocks (1mA). Propranolol (10mg/kg) injection was immediately followed retrieval of either a one-day recent (weak or strong) or 36-day remote (weak or strong) contextual fear memories. Results: We found that propranolol induced a long-lasting impairment of subsequent expression of recent and remote memories with either weak or strong strength. We also found no memory recovery after a weak reminder shock. Furthermore, no significant differences were found on the amount of memory deficit induced by propranolol among memories with different age and strength. Discussion: Our data suggest that the efficacy of propranolol in impairing fear memory reconsolidation is not limited to the age or strength of the memory.
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نویسندگان مقاله فاطمه طاهریان | fatemeh taherian
islamic azad university, damghan branch, damghan, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

عباسعلی وفایی | abbas ali vafaei
laboratory of learning and memory, research center and department of physiology, school of medicine, semnan university of medical sciences, semnan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

غلام حسن واعظی | gholam hassan vaezi
islamic azad university, damghan branch, damghan, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

شرف اسکندریان | sharaf eskandarian
islamic azad university, damghan branch, damghan, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

عادل کاشفی | adel kashefi
laboratory of learning and memory, research center and department of physiology, school of medicine, semnan university of medical sciences, semnan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

علی رشیدی پور | ali rashidy pour
laboratory of learning and memory, research center and department of physiology, school of medicine, semnan university of medical sciences, semnan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-213&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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