| چکیده انگلیسی مقاله |
Introduction: Tanacetum sonbolii (Asteraceae) is an endemic species in Iran. In the present study, we examined the effects of Tanacetum sonbolii hydroalcoholic extract on the formalin test in mice. Methods: 126 Swiss albino mice weighing 230-280g were used as subjects. The formalin test was performed on two control groups (marked as intact and saline groups n = 6 in each group) and an experimental group. In all groups, the formalin test was recorded for 60 min after administration of extract and drugs in mice. Results: The results showed that Tanacetum sonbolii (150 and 300 mg/kg) produced significant antinociception in phase 2. In addition, different doses of Tanacetum sonbolii extract (600, 900 and 1200 mg/kg) also induced antinociceptive effects in phase1 and phase 2. On the other hand, morphine could induce antinociception in a dose-dependent manner. Diclofenac (10 mg/kg) failed to affect the pain scores compared to Tanacetum sonbolii (300 mg/kg) group. Discussion: It seems that administration of hydroalcoholic extract of Tanacetum sonbolii has the potential to relieve pain through both central and peripheral mechanisms in persistent inflammatory nociception. |
| نویسندگان مقاله |
محمد صوفی آبادی | mohammad sofiabadi
cellular and molecular research center, qazvin university of medical sciences, qazvin, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)
حسن اژدری زرمهری | hassan azhdari zarmehri
department of basic sciences, torbat heydariyeh university of medical sciences, torbat heydariyeh, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تربت حیدریه (Torbat heydariyeh university of medical sciences)
فیروزه نادری | firiozeh naderi
cellular and molecular research center, qazvin university of medical sciences, qazvin, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)
mohhadese ghalandri | mohhadese ghalandri
physiology–pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)
علی سنبلی | ali sonboli
department of biology, medicinal plants and drugs research institute, shahid beheshti university, g.c., evin, tehran, iran.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)
عباس حق پرست | abbass haghprast
neuroscience research center, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
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