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Basic and Clinical Neuroscience، جلد ۵، شماره ۲، صفحات ۱۶۹-۱۷۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Effect of Extremely Low Frequency Electromagnetic Field and/or GABAB Receptors on Foot Shock-induced Aggression in Rats |
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| چکیده انگلیسی مقاله |
Introduction: The present study investigated the interactive effect of GABAB receptors and extremely low frequency electromagnetic field (ELF-EMF) on foot shock-induced aggression in rats. Methods: fifty adult male rats were randomly assigned into 10 groups. Groups 2, 4, 6, 8 and 10 were exposed to 50 Hz, 500 µT ELF-EMF for 30 days 8h per day while the remaining groups (1, 3, 5, 7 and 9) were sham-exposed. At the end of this period, the animals in groups 1 and 2 received normal saline while groups 3 and 4 treated with 100 mg/kg (low dose) of CGP35348 and groups 5 and 6 injected with 200 mg/kg (high dose) of CGP35348. Groups 7 and 8 treated with 1.7 mg/kg (low dose) of Baclofen and groups 9 and 10 received 3 mg/kg (high dose) Baclofen by IP injections. Twenty min after the injection, the aggressive behavior was recorded in foot shock-induced aggression model. The number of lateral threat, lifted up threat, biting, attacking, chasing and approaching were considered as paradigms of aggressive behavior. Results: ELF-EMF, Baclofen or CGP35348 alone had no significant effect on aggressive behavior. Except that rats exposed and treated with low dose of CGP35348 demonstrated significantly higher numbers of only one of the paradigms of aggressive behavior (lifted up threats), CGP35348 and Baclofen in both doses in combination with ELF-EMF exposure had no significant effect on aggression. Discussion: GABAB receptors and ELF-EMFs had no effect (both enhancement and suppression) on aggressive behavior of rats in foot shock-induced model of aggression. |
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| نویسندگان مقاله |
مهناز طاهریان فرد | mahnaz taherian fard
shiraz university, school of veterinary medicine, department of basic sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)
امین اله بهای الدینی | aminollah bahaeddini
shiraz university, school of sciences, department of biology, shiraz, iran
سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)
طهورا شمالی | tahoora shomali
shiraz university, school of veterinary medicine, department of basic sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)
سعیده کریمی حقیقی | saeideh karimi haghighi
shiraz university, school of veterinary medicine, department of basic sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-469-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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