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Basic and Clinical Neuroscience، جلد ۴، شماره ۲، صفحات ۱۷۲-۱۷۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Cell Therapy in Spinal Cord Injury: a Mini- Reivew |
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| چکیده انگلیسی مقاله |
Spinal cord injury (SCI) is a debilitating disease which leads to progressive functional damages. Because of limited axonal regeneration in the central nervous system, there is no or little recovery expected in the patients. Different cellular and molecular approaches were investigated in SCI animal models. Cellular transplantation of stem cells can potentially replace damaged tissue and provide a suitable microenvironment for axons to regenerate. Here, we reviewed the last approaches applied by our colleagues and others in order to improve axonal regeneration following SCI. We used different types of stem cells via different methods. First, fetal olfactory mucosa, schwann, and bone marrow stromal cells were transplanted into the injury sites in SCI models. In later studies, was applied simultaneous transplantation of stem cells with chondroitinase ABC in SCI models with the aid of nanoparticles. Using these approaches, considerable functional recovery was observed. However, considering some challenges in stem cell therapy such as rejection, infection, and development of a new cancer, our more recent strategy was application of cytokines. We observed a significant improvement in motor function of rats when stromal derived factor-1 was used to attract innate stem cells to the injury site. In conclusion, it seems that co-transplantation of different cells accompanies with other factors like enzymes and growth factors via new delivery systems may yield better results in SCI. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
ثریا محرابی | soraya mehrabi
ساناز افتخاری | sanaz eftekhari
bfateme مرادی | bfateme moradi
حمداله دلاویز | hamdollah delaviz
باقر پورحیدر | bagher pourheidar
منیر عزیزی | monir azizi
ادیب زنده دل | adib zendehdel1
علی شهبازی | ali shahbazi
محمد تقی جغتایی | mohammad taghi joghataei
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-158&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Original |
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