|
|
Basic and Clinical Neuroscience، جلد ۴، شماره ۱، صفحات ۳۱-۳۵
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics |
|
| چکیده انگلیسی مقاله |
Introduction: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. Methods: For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others. Results: Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups. Discussion: These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and .nd new effective substance against this kind of epilepsy. |
|
| کلیدواژه‌های انگلیسی مقاله |
Ciprofloxacin, Absence epilepsy, Wag/Rij, EEG |
|
| نویسندگان مقاله |
علی مقیمی | ali moghimi
the applied research center for neurofeedback and neurobehavioral sciences aren , ferdowsi university of mashhad, iran
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)
سمانه ملازاده | samaneh mollazadeh
biotechnology research center, bu-ali research institute, mashhad university of medical science, mashhad, iran.
فاطمه بهنام رسولی | fatemeh behnam rassouli
cell and molecular research group, institute of biotechnology, ferdowsi university of mashhad, mashhad, iran
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)
رضا shiee | reza shiee
department of signal and systems, chalmers university, sweden.
محمد علی خلیل زاده | mohammad ali khalilzade
mohammad ali khalilzade
|
|
| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-137&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Original |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|