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Basic and Clinical Neuroscience، جلد ۴، شماره ۱، صفحات ۵۷-۶۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats' Hippocampus |
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| چکیده انگلیسی مقاله |
Introduction MDMA or ecstasy is a derivative of amphetamines used mostly by young people worldwide. Although the acute effects of this drug are known, the effect of chronic administration is not well studied. Therefor the aim of this study was to determine the effects of repeated (long term) administration of MDMA on rats' memory and their hippocampal cell density. Method: Young adult male Wistar rats 200 ± 20 g served as subjects. The rats were randomly distributed into three MDMA treated groups (3×2.5 mg/kg, 3×5 mg/kg, 3×10 mg/kg) and one control-saline group. All animals received MDMA intraperitoneally (3h apart a challenge) 7th day of every week for consecutive 4 weeks. Animals were trained before and were tested after injections for their memory status using the standards passive avoidance method. Finally, 24hr after the memory test, rats were sacri.ced and after tissue operations, the hippocampal astrocytes and neurons were counted. Results: results showed that the number of neurons in all experimental groups was lower than the control-saline group. The most decreased number of neurons was shown in 5 mg/kg MDMA group compared to control-saline in all the regions of hippocampus. Also we found that repeated administration of MDMA reduced the number of hippocampal astrocytes. Discussion: It is concluded that repeated administration of MDMA can reduce density of neurons and astrocytes and this decrease is not dose dependence. |
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| کلیدواژه‌های انگلیسی مقاله |
Ecstasy, Neurons, Astrocytes, Passive Avoidance Memory |
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| نویسندگان مقاله |
مهرداد جهانشاهی | mehrdad jahanshahi
neuroscience research center, department of anatomy, golestan university of medical sciences, gorgan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)
کامران حیدری | kamran haidari
neuroscience research center, department of anatomy, golestan university of medical sciences, gorgan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)
سیمین محکی زاده | simin mahaki zadeh
neuroscience research center, department of anatomy, golestan university of medical sciences, gorgan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)
emsegol نیک محضر | emsegol nikmahzar
neuroscience research center, department of anatomy, golestan university of medical sciences, gorgan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)
فاطمه باباکردی | fatemeh babakordi
neuroscience research center, department of anatomy, golestan university of medical sciences, gorgan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-144&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Original |
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