|
|
Basic and Clinical Neuroscience، جلد ۴، شماره ۱، صفحات ۹۱-۹۶
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Octodon Degus: A Strong Attractor for Alzheimer Research |
|
| چکیده انگلیسی مقاله |
The most popular animal models of Alzheimer’s disease (AD) are transgenic mice expressing human genes with known mutations which do not represent the most abundant sporadic form of the disease. An increasing number of genetic, vascular and psychosocial data strongly support that the Octodon degus, a moderate-sized and diurnal precocial rodent, provides a naturalistic model for the study of the early neurodegenerative process associated with sporadic AD. In this minireview we describe and analyze the risk factors that contribute to Alzheimer-like characteristics in the degus, following recent publications, and establish some guidelines for future studies in this model of natural aging associated with the disease. Given the heterogeneity of current data derived from the diverse transgenic animal models of AD, now may be the time for the degus to become a strong attractor for academic research labs and companies involved with AD. This may help to understand the mechanisms responsible for the early neurodegenerative process associated with this devastating disease. |
|
| کلیدواژه‌های انگلیسی مقاله |
Animal model, Aging, Octodon degus, Alzheimer’s disease. |
|
| نویسندگان مقاله |
رافایل castro fuentes | rafael castro fuentes
department of physiology, school of medicine, university of la laguna, 38320 tenerife, spain.
rosario socas pérez | rosario socas pérez
department of cognitive psychology, school of psychology, university of la laguna. 38205 tenerife, spain.
|
|
| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-142&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Original |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|