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Basic and Clinical Neuroscience، جلد ۳، شماره ۵، صفحات ۳۶-۴۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Protective Effect of L-Arginine against Oxidative Damage as a Possible Mechanism of its Bene.cial Properties on Spatial Learning in Ovariectomized Rats |
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| چکیده انگلیسی مقاله |
Introduction: The role of ovarian hormones and nitric oxide (NO) on oxidative damage in brain tissues as well as learning and memory has been widely investigated.The present study was carried out to evaluate the effect of the precursor of NO, L-Arginine on learning and brain damage due to oxidative stress in ovariectomized (OVX) rats.Methods: Thirty -two rats were divided into four groups: 1) Sham, 2) OVX, 3) Sham-L-Arginine (Sham-LA) and 4) OVX-L-Arginine(OVX-LA). The animals of sham- LA and OVX-LA were treated with 500 mg/kg of L-Arginine. The animals in Sham and OVX groups received 1 ml/kg saline. The animals were tested in Morris water maze and .nally, the brains were removed and MDA and total thiol concentrations were measured.Results: The escape latency and swimming path in OVX group were signi.cantly higher than in Sham group (p< 0.01). The animals in OVX-LA group had signi.cantly lower swimming path length and escape latency compared to OVX group (p< 0.01) while, there was no signi.cant difference between Sham- LA and Sham groups. In OVX-LA group, the brain tissues total thiol concentration was signi.cantly higher, and MDA concentration was lower than of OVX group (p< 0.001).There was no signi.cant difference between Sham-LA and Sham groups. Discussion: It seems that the bene.cial properties of L-Arginine on spatial learning of ovariectomized rats are in part due to its protective capacity against oxidative damage. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
محمود حسینی | mahmoud hosseini
معصومه پورگنجی | masoume pourganji
فاطمه خدابنده لو | fatimeh khodabandehloo
محمد سوختانلو | mohammad soukhtanloo
هدی ذبیحی | hoda zabihi
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-129&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Original |
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