|
|
Basic and Clinical Neuroscience، جلد ۲، شماره ۴، صفحات ۱۲-۱۸
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Effect of Different Doses of Soy Isoflavones on Spatial Learning and Memory in Ovariectomized Rats |
|
| چکیده انگلیسی مقاله |
Introduction: Several studies indicate that estrogen use increase performance on some tests of cognition especially in postmenopausal women. These steroids have many side effects, thus, other estrogenic agents with fewer side effects are needed to develop alternative treatment strategies. The main objection of this study was to evaluate the effects of different doses of dietary soy meals (with or without isoflavone) on spatial learning and memory in ovariectomized (OVX) rats. Methods: Female Wistar rats with the exception of intact group were ovariectomized at the first line of study. Subjects were divided into six groups. The control group rats (c) were gonadally intact, while the others were OVX. OVX groups received normal diet (0), treated with 10 gr soy (10), 20 gr soy (20), 10 gr isoflavone free soy (-10) or 20 gr isoflavone free soy (-20) in daily diet for four weeks. The spatial learning and memory were tested using Morris water maze. Rats were trained in water maze to find a hidden escape Platform. Rats received 6 blocks that each block consisted of 3 trials. Following acquisition trials, one probe trial were conducted in which the platform was removed. Results: Soy meal diet (with or without isoflavone) in ovariectomized rats caused improvement of performance across 18 trials of Acquisition. Discussion: Our results suggest that soy consumption apart from containing isoflavone or not is a potential alternative to estrogen in the improvement of cognition. |
|
| کلیدواژه‌های انگلیسی مقاله |
Soy,Isoflavone,Morris water maze,Ovariectomy,Rat. |
|
| نویسندگان مقاله |
مریم صفاهانی | maryam safahani
رضا امانی | reza amani
هادی علیقلی | hadi aligholi
علیرضا سرکاکی | alireza sarkaki
محمد بدوی | mohammad badavi
احمد زندمقدم | ahmad zand moghaddam
محمدحسین حقیقی زاده | m hosein haghighizadeh
|
|
| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-71&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|