|
|
Basic and Clinical Neuroscience، جلد ۲، شماره ۴، صفحات ۴۷-۵۲
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژههای فارسی مقاله |
|
|
| عنوان انگلیسی |
Chronic Treatment by L-NAME differently Affects Morris Water Maze Tasks in Ovariectomized and Naïve Female Rats |
|
| چکیده انگلیسی مقاله |
Introduction: The role of ovarian hormones and nitric oxide (NO) in learning and memory and their interaction has been widely investigated. The present study carried out to evaluate different effect of L-NAME on spatial learning and memory of ovariectomized (OVX) and sham operated rats. Methods: 32 rats were divided into 4 groups: 1) Sham 2) OVX 3) Sham-LN and 4) OVX-LN. The animals of groups 3 and 4 were treated by L-NAME (10 mg/kg/ day) for 8 weeks while the animals of groups 1 and 2 received saline (1ml/kg/day) instead of L-NAME. The animals of all groups were then tested in Morris water maze during five days. The escape latency and traveled distance were compared between groups. Results: Distance and time in OVX group was significantly higher than Sham group (p< 0.01 and p< 0.05). Time and distance in Sham-LN group was higher in comparison with Sham group (p< 0.05 and p< 0.01). There were no significant differences between OVX-LN and OVX groups in escape latency and traveled distance. Discussion: The results of present study showed that removal of ovarian hormones could impair Morris water maze tskas includiong time and distance. Administarion of non specific nitricoxide inhibitor, L-NAME, affects Morrsi water maze tasks however, its effect is different in the absence and presence of ovarian hormones but it needs to be more investigated. |
|
| کلیدواژههای انگلیسی مقاله |
Ovariectomy,Female Rat,Morris Water Maze,Morris Water Maze |
|
| نویسندگان مقاله |
محمود حسینی | mahmoud hosseini
آزاده فیض پور | azadeh feizpour
محسن رضایی پور | mohsen rezaeipour
عاطفه امانی | atefeh amani
فاطمه صفارزاده | fatima saffarzadeh
اسماعیل فرخی | esmaeil farrokhi
|
|
| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-75&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|