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Basic and Clinical Neuroscience، جلد ۲، شماره ۴، صفحات ۵۳-۵۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze |
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| چکیده انگلیسی مقاله |
Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior in mice. Methods: Male mice were intraperitoneally (i.p.) administrated sildenafil (1, 2, or 10 mg/kg), and the control group was given the vehicle 15 min before the plus-maze test. The number of entries into the open arms of the plus-maze, the time spent in the open arms, and the total numbers of entries into the arms were recorded. Results: The results indicated that compared to the control group, the sildenafil-treated mice spent more time in the open arms and had a greater number of entries into open arms. The total number of entries into the arms did not significantly differ between the sildenafil-treated groups and the control group. Discussion: Acute administration of sildenafil could have anxiolytic effects on male mice. This effect might be mediated in a time-dependent manner by the NO/ cGMP/PDE5 pathway. |
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| کلیدواژه‌های انگلیسی مقاله |
Anxiety,Sildenafil,Acute,Elevated Plus-Maze,Mice. |
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| نویسندگان مقاله |
سیامک شهیدی | siamak shahidi
نسرین هاشمی فیروزی | nasrin hashemi firouzi
مینو محمودی | minoo mahmoodi
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-76&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
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