|
|
Basic and Clinical Neuroscience، جلد ۲، شماره ۲، صفحات ۲۶-۳۰
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Prenatal Mercuric Chloride Exposure Causes Developmental Deficits in Rat Cortex |
|
| چکیده انگلیسی مقاله |
Introduction: Environmental pollution with heavy metals such as mercury is a major health problem. Growing studies on the field have shown the deleterious effects of mercury on human and nonhuman nervous system, especially in infants, however the effects of prenatal exposure to mercuricchloride on cortical development are not yet well understood. The aim of this study was to investigate the effect of prenatal exposure to mercuric chloride on morphological characteristics of brain cortex. Methods: Mercuric chloride (2 mg/kg) or normal saline were injected (I.P.) to 36 Sprague – dawley rats in the 8th, 9th or 10th day of gestation. The embryos were surgically removed in the 15th day of gestation, and brain cortices were studied by histological techniques. Results: Histological studies showed that embryos of mercuric chloride treated rats hadcortical neuronal disarrangement withdifferent orientations of nuclei, increased diameter of cortex, increased mitosis of cells, increased cell death, decreased cellular density and increased intracellular space. Conclusion: These findings suggest some micro structural abnormalities in cortical regions after prenatal exposure to mercuric chloride. These structural abnormalities may underliesome neurologic disturbances following mercury intoxication. |
|
| کلیدواژه‌های انگلیسی مقاله |
Mercuric Chloride,Prenatal Period,Brain Cortex |
|
| نویسندگان مقاله |
طیبه رستگار | tayebeh rastegar
کاظم پریور | kazem parivar
ملیحه نوبخت | maliheh nobakht
علی شهبازی | ali shahbazi
سیامک علیزاده zendehrood | siamak alizadeh zendehrood
مهدی مهدی زاده | mehdi mehdizadeh
|
|
| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2-17&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|