|
|
Basic and Clinical Neuroscience، جلد ۲، شماره ۱، صفحات ۱۳-۱۹
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Blockade of Opioid Receptors Located in the Rat Nucleus Cuneiformis Reduced the Antinociceptive Responses of Local But not Systemic Administration of Morphine in Formalin Test |
|
| چکیده انگلیسی مقاله |
ABSTRACTPrevious studies have shown the role of opioid receptors located in the nucleus cuneiformis (CnF) in acute pain, but not in chronic pain models. In the present study, we have determined that possible effects of these receptors at the CnF on both early and late phases of formalin test following local and systemic morphine administration. Each rat was given a subcutaneous 50-μl injection of 2.5% formalin into plantar surface of hind paw. Ninety five Wistar rats bilaterally received morphine (1, 2, 4 and 8 μg/0.3 μl saline per side) into the CnF, just before the formalin test. Naloxone (1 μg/0.3 μl saline per side) was also microinjected 2 minutes before local or 28 minutes after intraperitoneal administration of morphine. The results showed that bilateral intra-CnF administration of morphine dose-dependently produced analgesia in formalin test. Naloxone administration into the CnF antagonized the analgesic response induced by morphine (4 μg/0.3 μl saline) microinjection. The results also showed that analgesic effect of systemic morphine was not significantly decreased by naloxone microinjection. We suggest that the opioid receptors located in the CnF, in part, indirectly affect the morphine-induced descending pain modulatory circuit. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
عباس حق پرست | abbas haghparast
لیلا احمد مولایی | leila ahmad molaei
امیر محمد علیزاده | amir mohammad alizadeh
پگاه عزیزی | pegah azizi
|
|
| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2-4&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Original |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|