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Basic and Clinical Neuroscience، جلد ۱، شماره ۳، صفحات ۴۹-۵۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Electrophysiological Study of Sciatic Nerve Regeneration Through Tubes Seeded with Schwann Cells |
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| چکیده انگلیسی مقاله |
A B S T R A C TIntroduction: Peripheral nerve injury is a common disorder and leads to permanent neurological defects. Schwann cells have been shown to have nerve repair after being transplanted in peripheral nerve injury. The aim of this study was to determine the beneficial effect of allograft Schwann cells on electrophysiological outcome after transection of the sciatic nerve in rats.Methods: Twenty adult male Wistar rats (200-250 g) were used in this study and left sciatic nerve was cut 10 mm in all of them and randomly divided into two groups. Then, the experimental (n=10) and control (n=10) groups received silicon tube with Schwann cells and silicon tube without Schwann cells respectively. Electrophysiological studies were performed 8 weeks after transplantation. Results: Electrophysiological study in experimental animals showed that amplitude of nerve action potential is higher and latency is less as compared to the control group (p< 0.05). Discussion: The combination of different strategies such as silicon tube and Schwann transplantation has a more effective role in nerve repair. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
مهرداد بختیاری | mehrdad bakhtyari
0098-09124935972 e-mail habootaleb92@gmail.com
حمید ابوطالب | hamid abootaleb
department of anatomy and neuroscience research center, iran university of medical sciences,
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
کورش منصوری | korosh mansouri
department of physical medicine and rehabilitation, iran university of medical sciences,
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-33&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and molecular Neuroscience |
| نوع مقاله منتشر شده |
Original |
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