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Basic and Clinical Neuroscience، جلد ۱، شماره ۲، صفحات ۳۰-۳۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
The beneficial effect of the flavonoid quercetin on behavioral changes in hemi-Parkinsonian rats |
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| چکیده انگلیسی مقاله |
Introduction: A large body of experimental evidence supports a role for oxidative stress as a mediator of nerve cell death in Parkinson's disease (PD). Flavonoids like quercetin have been reported to prevent neuronal degeneration caused by increased oxidative burden, therefore, this study examined whether quercetin administration at a high dose would attenuate behavioral abnormalities in experimental model of PD in rat. Methods: For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with quercetin (20 mg/kg i.p.) 1 hour before surgery and treated once a day for one month. After one month, apomorphine-induced rotational behavior was measured postlesion. Results: Apomorphine-induced rotations were counted after 4 weeks. Quercetin administration could attenuate the rotational behavior in treated lesioned rats as compared to untreated ones. Discussion: Flavonoid quercetin administration for one month could attenuate behavioral abnormalities in 6-OHDA model of PD. |
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| کلیدواژههای انگلیسی مقاله |
Quercetin, 6-Hydroxydopamine, Parkinson’s disease, Rat |
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| نویسندگان مقاله |
مهدی مهدی زاده | mehdi mehdizadeh
محمد تقی جغتایی | mohammad taghi joghataei
ملیحه نوبخت | maliheh nobakht
رویا آریانپور | roya aryanpour
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-23&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original |
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