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Basic and Clinical Neuroscience، جلد ۱، شماره ۱، صفحات ۳-۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Neuroprotective effect of quercetin in a model of Parkinson’s disease in rat: A histochemical analysis |
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| چکیده انگلیسی مقاله |
AbstractIntroduction: Parkinson's disease (PD) is a neuropathological disorder involving the degeneration of dopaminergic neurons in the substantia nigra, with the subsequent loss of their terminals in the striatum. Quercetin, a natural flavonoid, is a strong antioxidant and radical scavenger. Therefore, its neuroprotective effect in a model of Parkinson’s disease in rat was evaluated.Methods: For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with quercetin (20 mg/kg i.p.) 1 hour before surgery and treated once a day for one month. Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted. Results: Number of Nissl-stained neurons in left side of SNC of lesion group was lower relative to sham-operated group (p< 0.005) and it was higher in quercetin-treated lesion group as compared to untreated lesion group (p< 0.01).Discussion: Flavonoid quercetin administration for one month could protect the neurons of SNC against 6-OHDA toxicity. |
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| کلیدواژه‌های انگلیسی مقاله |
Quercetin, 6-Hydroxydopamine, Parkinson’s disease, Rat |
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| نویسندگان مقاله |
مهدی مهدی زاده | mehdi mehdizadeh
depertemenet of anatomy, iran university of medical sciences, tehran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
محمد تقی جغتایی | mohammad taghi joghataei
ملیحه نوبخت | maliheh nobakht
رویا آریانپور | roya aryanpour
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-1&slc_lang=en&sid=en |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original |
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