| چکیده انگلیسی مقاله |
Introduction: Obsessive-Compulsive Disorder (OCD) as one of the important mental problems is valuable topic for proteomic research studies to better understand the underlying mechanisms of this disorder. Methods: In this paper, gel-based proteomic was used to investigate the proteome profile of 16 female patients with OCD, washing subtype before and after treatment with fluoxetine and comparing them with 20 healthy female controls. Results: One of the abnormally expressed protein spots in this study was introduced and examined for protein-protein interaction network analysis via Cytoscape and its plug-ins. Transthyretin (TTR) protein showed significant expression changes (fold change =1.7, P< 0.05). While the expression level of TTR is significantly decreased in OCD patients before any treatments, the trend is partially normalized after treatment with fluoxetine in positive responders. Furthermore, TTR interaction profile shows that the proteins interacting with this protein may get affected as this protein expression trend changes in OCD patients. Conclusion: TTR can be considered for further studies to be validated as a potential biomarker for OCD. |
| نویسندگان مقاله |
| Mona Zamanian Azodi
Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Mostafa Rezaei Tavirani
Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Afsaneh Arefi Oskouie
Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Vahid Mansouri
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Mostafa Hamdieh
Department of Psychology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Naser Nejati
Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Mohsen Hamidpour
Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Alireza Ahmadzadeh
Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Mohammad Rostami-Nejat
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Majid Rezaei Tavirani
Department of Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Seyed Abdolreza Mortazavi Tabatabaei
Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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