Introduction: Odontogenic tumors include a variety of lesions that are classified from hamartomas to benign and malignant neoplasms. Angiogenesis process helps neoplastic tissue to gain an adequate supply of oxygen and also to remove the waste products. Mean Vessel Density (MVD) evaluation is a common method for assessing angiogenesis by using different markers. To the best of our knowledge, there is no specific marker for angiogenesis evaluation, so the aim of this study is to determine the proper angiogenic marker.

Materials & methods: In this cross sectional study, the MVD was assessed 45 cases totally; 15 cases in each group. Data were analyzed by using independent t-test and one-way ANOVA (P<0.05).

Results: There are statistically significant differences between CD34 and CD105 (P=0.028), CD34 and VEGF (P=0.001) and, CD105 and VEGF (P=0.001). CD34 has the lowest sensitivity, and VEGF has the highest sensitivity among others.

Conclusion: The results suggest that VEGF could be a better marker for assessing angiogenic tissue.