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Basic and Clinical Neuroscience، جلد ۹، شماره ۵، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Serum Proteomic Study of Women With Obsessive-Compulsive Disorder, Washing Subtype |
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| چکیده انگلیسی مقاله |
Introduction: Many genetic studies are conducted on Obsessive-Compulsive Disorder (OCD). however, a high-throughput examination of proteome profile of this severe disease has not been performed yet. Methods: Here, the proteomic study of OCD patients' serum samples was conducted by the application of Two-Dimensional Electrophoresis (2DE) followed by Mass Spectrometry (MALDI-TOF-TOF). Results: A total of 240 protein spots were detected and among them, five significant differentially expressed protein spots with the fold change of ≥1.5 were considered for further evaluations. These proteins include IGKC, GC, HPX, and two isoforms of HP. The first two show down-regulation while the last one indicate up-regulation. Moreover, a validation study of overall HP levels in patients' serum via nephelometric quantification confirmed the lower levels of this protein in the serum of OCD patients. Additionally, enrichment analysis and validation test revealed that inflammation is one of most dominant processes in OCD. Conclusion: It is suggested that these candidate proteins and their underlying processes (especially, inflammation) may be linked to OCD pathophysiology and can promise a clinical use after extensive validation studies. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
| Mona Zamanian-Azodi
National Elites Foundation, Tehran, Iran.
| Mostafa Rezaei-Tavirani
Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Mohammad Mahboubi
| Mohsen Hamidpour
Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Majid Rezaei Tavirani
Department of Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Mostafa Hamdieh
| Mohammad Rostami-Nejad
Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Naser Nejadi
Department of Clinical Biochemistry, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
| Mohammad Kamran Derakhshan
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-941-4&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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