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Journal of Pediatrics Review، جلد ۲، شماره ۲، صفحات ۷۲-۷۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Eradication of Helicobacter pylori with triple therapy regimen (omeprazole, clarithromycin and amoxicillin) in children for seven days (A Pilot Study) |
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| چکیده انگلیسی مقاله |
Background and purpose: Successful treatment of Helicobacter pylori infection causes not only eradication of pathogen, but also prevents the associated diseases such as peptic ulcer, gastric carcinoma and lymphoma. The aim of this study was to evaluate the efficacy of 7 days triple therapy as a lowest drug resistance, shortest duration and fewer numbers of drugs in children. Materials and Method: The target population was 22 children < 15 years with peptic disease complaints. The inclusion criteria were: positive endoscopic finding, inflammatory evidence in gastric biopsy and presence of Helicobacter pylori in gastric mucosa. Two pieces from incisura and body of gastric mucosa were taken and stained with Gimsa. Helicobacter pylori positive patients were treated with omeprazol, clarithromycin and amoxicillin for 7 days. One month later, all cases were evaluated by repeated endoscopy or Urea Breath Test and H pylori eradication were assessed. Data was gathered and analyzed with SPSS software, and McNamara's and Chi-Square test were performed. Results: Nineteen patients were studied including twelve boys, 26.3% 2-6 years and the rest older than 6 years. The most common clinical presentations and endoscopic findings were chronic abdominal pain (74%) and nodularity (47.4%), respectively. The per-protocol and intention-to-treat H. pylori eradication rates were 84.2% and 76%, respectively in seven days triple therapy regimen. Conclusion: Seven days triple therapy successfully eradicated H pylori in children. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
مهری نجفی | mehri najafi
children medical center hospital, tehran university of medical sciences, tehran-iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
فریبا صیقلی | fariba seighali
maternal, fetal and neonatal research center, tehran university of medical sciences, blood transfusion research center, high institute for research and education in transfusion medicine, tehran-iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
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| نشانی اینترنتی |
http://jpr.mazums.ac.ir/browse.php?a_code=A-10-94-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
گوارش کودکان |
| نوع مقاله منتشر شده |
Original Article |
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