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Iranian Journal of Health Sciences، جلد ۴، شماره ۲، صفحات ۱۱-۱۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Application of the Weibull Accelerated Failure Time Model in the Determination of Disease-Free Survival Rate of Patients with Breast Cancer |
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| چکیده انگلیسی مقاله |
Background and Purpose: The goal of this study is application of the proportional hazards model (PH) and accelerated failure time model (AFT), with consideration Weibull distribution, to determine the level of effectiveness of the factors affecting on the level of disease-free survival (DFS) of the patients with breast cancer. Materials and Methods: Based on the retrospective descriptive studies, 377 female patients with primary breast cancer that had been treated at oncology section (Omid Hospital) in Mashhad, Iran, were considered for participation in the study. Results: The median was 2 years and 10 months (mean 2 years and 4 months, interquartile range 3 years and 7 months, range 1-2920 days or 8 years). The average age of patients was 49.2 ± 11.5 (range 25-80 years). The rate of DFS determined with 52.5%. Base on the result of PHs Weibull model, the risk of the metastasis after surgery in the patients with invasive tumors to the skin and chest and positive lymph node was more than 2 times [hazard ratio (HR) = 2.53; confidence interval (CI): 1.26, 5.06] and (HR = 2.37 CI: 1.42, 3.98), respectively. Hormone therapy after surgery decreases the risk of the metastasis to 0.63% (HR = 0.63; CI: 0.41, 0.95). In the AFT model, characteristic tumor decelerated (γ < 1) the DFS time by a factor of 0.30 and 0.33, respectively. Furthermore, the hormonal therapy accelerated (γ > 1) the DFS time by factor of 1.8. Conclusion: In this study, the PH and AFT assumption have been satisfied by data and characteristics tumor and the hormonal therapy decrease and increases time until recurrence, respectively. |
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| نویسندگان مقاله |
نرگس قربانی | narges ghorbani
epartment of biostatistics, school of public health, and student research committee, mazandaran university of
سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)
جمشید یزدانی چراتی | jamshid yazdani charati
department of biostatistics, school of public health and health sciences research center, mazandaran university of
سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)
کاظم انوری | kazem anvari
school of medicine, cancer research center, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
نسرین قربانی | nasrin ghorbani
medical records technician, omid hospital, mashhad, iran
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| نشانی اینترنتی |
http://jhs.mazums.ac.ir/browse.php?a_code=A-10-60-2&slc_lang=fa&sid=en |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
آمار زیستی |
| نوع مقاله منتشر شده |
پژوهشی |
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