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Immunoregulation، جلد ۱، شماره ۳، صفحات ۱۵۳-۱۵۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Blockade of Hypoxia: The Impact on Tumor Growth in an Experimental Tumor Model |
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| چکیده انگلیسی مقاله |
Background: Tumor microenvironment is an active factor participating in immunoregulation, thereby preventing immunosurveillance and limiting the efficacy of anticancer therapies. Hypoxia as a major characteristic of solid tumors causes the expression of Hypoxia-Inducible Factor-1α (HIF-1α). This is a transcription factor that mediates hypoxic responses of tumor cells and involves in the expression of tumor immunosuppression-related genes. Materials and Methods: In this study, we used a mouse 4T1 breast cancer model.Results: Our obtained data revealed that in vivo administration of PX-478, an inhibitor of oxygen sensitive HIF-1α, reduced the expression of Forkhead box P3 (Foxp3) transcript, a molecule that is directly controlled by HIF-1. The level of vascular endothelial growth factor, another gene controlled by HIF-1, remained unchanged. The observed results were in correlation with delayed tumor growth in tumor-bearing mice.Conclusion: Our findings indicate that the reduction in Foxp3 expression through HIF-1α inhibition using PX-478 may contribute to tumor regression. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
Nasim Kheshtchin |
Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Samaneh Arab |
Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Jamshid Hadjati |
Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://immunoreg.shahed.ac.ir/article_817_a559497397a459f84007e8b089a006dd.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2435/article-2435-1533381.pdf |
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| زبان مقاله منتشر شده |
en |
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