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Immunoregulation، جلد ۱، شماره ۳، صفحات ۱۵۹-۱۶۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria |
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| چکیده انگلیسی مقاله |
Background: The immunologic profile of chronic urticaria is not only important for diagnostic purposes, but also for therapeutic approaches. This study evaluated the serum levels of Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α) and Interferon-ϒ (IFN-ϒ) in patients with chronic urticaria to find a biomarker.Materials and Methods: Forty-one patients with chronic urticaria referring to the Allergy Outpatient Clinic of Rasoul Akram Hospital and 20 healthy control subjects were enrolled in the study. A questionnaire was filled and the disease activity score was determined in a one-week period for every patient. All patients underwent basic laboratory tests in addition to the Autologous Serum Skin Test. Their serum IL-6, TNF-α, and IFN-ϒ levels were also evaluated.Results: The patients were divided into two groups comprising of 20 and 21 participants according to the results of Autologous Serum Skin Tests. The serum IL-6 levels were elevated in the patients' group (P=0.015). However, there was no significant difference between the patients with chronic urticaria and healthy controls in the serum levels of TNF-α (P=0.25), and IFN-ϒ (P=0.55), neither in the exact state nor by the Mann-Whitney U test.Conclusion: Serum IL-6 level was elevated in patients with chronic urticaria, but the serum levels of IFN-ϒ and TNF-α were not significantly elevated. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
Delara Babaie |
Department of Allergy and Clinical Immunology, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Nabavi |
Department of Allergy, Hazrat Rasul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Saba Arshi |
Department of Allergy, Hazrat Rasul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Houshang Gorjipour |
Department of Allergy and Clinical Immunology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.
Sepideh Darougar |
Department of Allergy and Clinical Immunology, Faculty of Medicine, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
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| نشانی اینترنتی |
http://immunoreg.shahed.ac.ir/article_818_ebdc5f4600e49d74e7950a82091e8a5a.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2435/article-2435-1533382.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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