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، جلد ۱۰، شماره ۵، صفحات ۴۵-۵۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Ameliorative Role of Palmitoleic Acid on Palmitate Induced Lipotoxicity in the Rat Cardiomyocytes |
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| چکیده انگلیسی مقاله |
Background: Co-supplementation of unsaturated fatty acids (FAs) with saturated FAs may decrease the adverse effects of saturated FA-induced lipotoxicity. The objective of the present study was to evaluate the effect of palmitoleic acid (unsaturated fatty acid) on palmitic acid (saturated fatty acid) induced lipotoxicity criteria in the primary culture of adult rat cardiomyocytes. Methods: Cells were treated with 0.5 mM palmitic acid, palmitoleic acid, palmitic + palmitoleic acids or remained untreated. The values of cellular triacylglycerol (TAG), diacylglycerol (DAG), DNA fragmentation and cellular viability were evaluated over 24 h, 48 h and 72 h time points. Results: Co-administration of palmitic and palmitoleic acids increased TAG values over 48 h and 72 h time points compared to the palmitic acid (34.37% and 62.79%, respectively; P < 0.001), while decreased DAG values (18.85% and 29.42%, respectively; P < 0.01). Moreover, palmitoleic acid decreased DNA fragmentation and increased viability when administrated with palmitic acid (P < 0.05). Conclusion: Palmitoleic acid may be beneficial for diminishing adverse effects of palmitic acid in the rat cardiomyocytes through alterations in the molecule signaling levels. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
| Elham Zadeh Hashem
Department of Pharmacology and Toxicology, Urmia University, Urmia, Iran.
| Mohammad Kazem Koohi
Department of Basic Sciences, University of Tehran, Tehran, Iran.
| Mohsen Eslami
Department of Theriogenology, Urmia University, Urmia, Iran.
| Farzad Asadi
Department of Biochemistry, University of Tehran, Tehran, Iran.
| Reza Taleb Zadeh
Department of Biochemistry, University of Tehran, Tehran, Iran.
| Mina Khodadadi
Department of Biochemistry, University of Tehran, Tehran, Iran.
| Sepideh Hassani-Dizaj
Department of Pharmacology and Toxicology, Urmia University, Urmia, Iran.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-366-1&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049625.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
پژوهشی |
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