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، جلد ۷، شماره ۲۳، صفحات ۹۴۴-۹۵۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
The Effect of Rebadioside A on Attenuation of Oxidative Stress in Kidney of Mice under Acetaminophen Toxicity |
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| چکیده انگلیسی مقاله |
Background: Acetaminophen (APAP) overdose causes renal and hepatic injury. It is also believed that oxidative stress has a pivotal role in APAP-induced renal injury. Therefore, protective effects of different antioxidants have been examined in APAP-induced renal and hepatic toxicity models. Stevia rebadiana is a plant with a high degree of natural antioxidant activity in its leaf extract. The aim of this study was to investigate the possible protective effects of rebadioside A one of the main components of stevia extract, on APAP-induced oxidative stress in kidney of mice. Methods: Oxidative stress was induced in kidney of BALB/c mice by the intraperitoneal (i.p.) administration of a single dose of 300 mg/kg APAP. Some of these mice also received rebadioside A (700 mg/kg) (i.p.) 30 minutes after APAP injection. Two and six hours after APAP injection, all mice were sacrificed and malondialdehyde (MDA), glutathione (GSH), free APAP, and glutathione conjugated of APAP (APAP-GSH) were determined in the kidney tissue. Results: GSH depletion and MDA levels significantly (P< 0.05) increased in mice treated with either APAP or APAP plus Rebadioside A, respectively in 2 and 6 hours intervals after APAP administration. Significantly (P< 0.05) higher levels of free APAP and APAP-GSH levels detected in kidney of mice administrated with APAP plus rebadioside A compared to APAP treated ones. Conclusion: Rebadioside A may be a potential compound in alleviation of APAP-induced oxidative stress in kidney of mice after APAP overdoses. |
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| کلیدواژههای انگلیسی مقاله |
Acetaminophen, Oxidative Stress, Rebadioside A. |
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| نویسندگان مقاله |
سیدعلی هاشمی | Seyed Ali Hashemi
Department of Clinical Biochemistry, Tarbiat Modares University, Tehran, Iran.
عبدالامیر علامه | Abdolamir Allameh
Department of Clinical Biochemistry, Tarbiat Modares University, Tehran, Iran.
بهرام دارایی | Bahram Daraei
Department of Toxicology, Tarbiat Modares University, Tehran, Iran.
کامران مرادی پینوندی | Kamran Moradi Peynevandi
Department of Plant Physiology, Tarbiat Modares University, Tehran, Iran.
رامین پاشازاده | Ramin Pashazadeh
Department of Chemistry, Tarbiat Modares University, Tehran, Iran.
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-138&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049730.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
پژوهشی |
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