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، جلد ۲، شماره ۳، صفحات ۲۲۱-۲۲۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of Anticonvulsant Effects of Nimodipine and Ascorbic Acid on Pentylenetetrazole- Induced Seizures in Mice |
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| چکیده انگلیسی مقاله |
Introduction: The mechanisms underlying the vulnerability of the brain to seizures remains unknown. Calcium ions influx and oxidative stress have been implicated in a variety of acute and chronic epileptogenic conditions. The present study was aimed at investigating the effects of nimodipine and ascorbic acid (vitamin C) alone and in combination on pentylenetetrazole (PTZ) - induced seizures in mice. Material and methods: The animals received nimodipine (0.5, 1, 1.5, 2 mg/Kg, i.p.), ascorbic acid (30, 100, 300 mg/Kg, i.p.) alone and in combination with sodium valproate (100 mg/Kg, i.p.), 15 and 30min prior to intra-peritonral injection of PTZ (60 mg/Kg) and the acute seizure parameters such as seizure latency, duration and protection percent were studied in each group. Results: Ascorbic acid alone did not have any effects on the seizure parameters and the number of mice convulsing ( P>0.05). Nimodipine in 2 mg/kg dose had full protective effect on PTZ- induced seizure parameters, and in lesser doses it exerted partial protective effects. The combination of ascorbic acid (300 mg/Kg) with nimodipine (1.5 mg/Kg) or sodium valproate had a significant synergistic protective effect against PTZ- induce seizures in comparison with controls( P< 0.001). Conclusion: Ascorbic acid potentiates the anticonvulsive effects of nimodipine on PTZ-induced seizure in mice. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
کامبیز سلطان نژاد | Kambiz Soltaninejad
Department of Forensic Toxicology, Legal Medicine Organization of Iran, Tehran, Iran
شاهین شادنیا | Shahin Shadnia
Loghman-Hakim Hospital Poison Center and Toxicology Resaerch Center,Faculty of Medicine, Shahid Beheshit Medical Sciences University, Tehran, Iran
فاطمه حسنی نژاد | Fatemeh Hasaninejad
Department of Toxicology, and Pharmacology,Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
فریبا جابری | Friba Jabbari
Department of Toxicology, and Pharmacology,Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
محمد عبدالهی | Mohammad Abdollahi
Department of Toxicology, and Pharmacology,Faculty of Pharmacy; and Pharmaceutical Sciences Research Center.Tehran Medical Sciences University, Tehran, Iran
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| نشانی اینترنتی |
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-47&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2737/article-2737-2049846.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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