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Journal of Pharmacoeconomics and Pharmaceutical Management، جلد ۳، شماره ۱/۲، صفحات ۲۱-۲۳
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| عنوان انگلیسی |
A cost minimization analysis of Azelastine/Fluticasone combination nasal spray versus Azelastine and Fluticasone nasal sprays monotherapy in moderate to severe allergic rhinitis in Iran |
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| چکیده انگلیسی مقاله |
Background: Allergic Rhinitis (AR) is a symptomatic disorder which is due to allergen exposure and IgE inflammatory pathway activation in respiratory tract. The present study’s purpose was to assess Azelastine/Fluticasone combination nasal spray cost-effectiveness in comparison with Azelastine and Fluticasone nasal sprays monotherapy, in mild to moderate AR patients in Islamic Republic of Iran (I.R.I.) health care system.
Methods: A literature review was performed in order to compare the effectiveness of Fluticasone/Azelastine (50μg/125μg) with Fluticasone (50μg) and Azelastine (125μg). The search was conducted in PubMed, ISI, Scopus, Cochrane, CRD York and Google Scholar based on a predefined PICO of the study. According to confirmed equal clinical effectiveness of two arms, a cost minimization analysis was done. As micro costing, direct medical costs (drugs` costs, GP office visits, office visit and allergy-related tests), based on official tariffs in Iran were calculated in a 14-day time horizon. Because of model’s time horizon, which was less than 1 year, discount rate was not applied.
Results: The result of literature search were two RCTs in which the combination form had been compared with each of the spray of Azalastine and Fluticasone. Azelastine/Fluticasone would save 2.05$ per patient for each course of treatment; and therefore recognized as cost-effective.
Conclusions: This study showed that Azelastine/Fluticasone combination was the cost saving alternative. |
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| نویسندگان مقاله |
| Nayyereh Ayati
Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Pharmaceutical Management and Economics Research Centre, Tehran University of Medical Sciences, Tehran, Iran
| Delara Babaie
Department of Allergy and Clinical Immunology, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Shekoufeh Nikfar
Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Pharmaceutical Management and Economics Research Centre, Tehran University of Medical Sciences, Tehran, Iran
| Erfan Rohani
Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Pharmaceutical Management and Economics Research Centre, Tehran University of Medical Sciences, Tehran, Iran
| Marzieh Nosrati
Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Pharmaceutical Management and Economics Research Centre, Tehran University of Medical Sciences, Tehran, Iran
| Pardis Zaboli
Iran Drug Selection Department, Iran Food and Drug Administration (IFDA), Tehran, Iran
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| نشانی اینترنتی |
http://jppm.tums.ac.ir/index.php/jppm/article/view/51 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2743/article-2743-2050422.pdf |
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