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Iranian Journal of Veterinary Medicine، جلد ۱۳، شماره ۴، صفحات ۳۳۲-۳۴۱
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| عنوان فارسی |
اثر عصاره برگ گیاه کهن دار(EGb ۷۶۱) برروی تغییرات پارامترهای هماتولوژیک و شکنندگی اسمزی گلبولهای قرمز خون رت های مواجهه داده شده با سم کلرپریفوس |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Ginkgo biloba Leaf Extract (EGb 761) on Changes in Haematological Parameters and Erythrocyte Osmotic Fragility in Hypotonic and Chlorpyrifos Exposed Rats |
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| چکیده انگلیسی مقاله |
BACKGROUND: Canine low-dose sepsis model provides a reliable setting to study innovative drugs. Lipopolysaccharides (LPS), a major constituent of bacterial outer membrane, have been demonstrated to play a critical role in the initiation of pathogenesis. Lipopolysaccharide-induced sepsis has been extensively studied in laboratory animals; but its importance has mainly remained unknown in dogs. OBJECTIVES: The aim of the present survey was to examine the effectiveness of quercetin, along with hydrocortisone on clinical and hematological alterations, and organ failure (liver and heart) in low-dose lipopolysaccharide-induced canine sepsis model. METHODS: For this purpose, fifteen clinically healthy mixed dogs were randomly divided into three equal groups. Lipopolysaccharide (0.1 μg/kg, IV) was injected to dogs in group A (control). Group B was similar to group A, but quercetin bolus (2 mg/kg, IV, once) was injected 40 minutes after LPS injection. Group C was similar to group B; however, hydrocortisone bolus (2 mg/kg, IV, once) was administered instead of quercetin. Serum levels of glucose, total protein, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatine kinase isoenzyme muscle/brain (CK-MB), lactate dehydrogenase (LDH) and cardiac troponin I (cTn-I) concentration were measured by commercial kits. RESULTS: In control group, red blood cells (RBCs), hemoglobin (Hb), and hematocrit (HCT) significantly decreased and serum activities of AST, ALP, LDH, CK-MB, and plasma cTn-I significantly increased (P< 0.05). RBCs, Hb, and HCT significantly increased in quercetin group, compared with hydrocortisone and control groups (P< 0.05). Quercetin group significantly decreased LDH, CK-MB, and cTn-I compared with hydrocortisone and control groups (P< 0.05). Quercetin significantly decreased AST in comparison to control group and ALP in comparison to hydrocortisone group, also (P< 0.05). CONCLUSIONS: These results suggest that quercetin protects RBCs in the early stages of sepsis and decreases organs dysfunction (heart and liver), therefore it has a positive influence on sepsis and may be more effective than routine corticosteroid (hydrocortisone) therapy. |
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| کلیدواژه‌های انگلیسی مقاله |
Chlorpyrifos, Ginkgo biloba, haematology, rats, vitamin E |
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| نویسندگان مقاله |
Sani Abdulrazak |
1Department of Veterinary Physiology, Ahmadu Bello University, P.M.B. 1069, Zaria, Kaduna, Nigeria.
2Department of Chemistry, Ahmadu Bello University, P.M.B. 1069, Zaria, Kaduna, Nigeria.
Adulmumin Abdulkabir Nuhu |
Department of Chemistry, Ahmadu Bello University, P.M.B. 1069, Zaria, Kaduna, Nigeria.
Zakka Yashim |
Department of Chemistry, Ahmadu Bello University, P.M.B. 1069, Zaria, Kaduna, Nigeria.
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| نشانی اینترنتی |
https://ijvm.ut.ac.ir/article_73999_a0528a9048bdccf39589a2a9abe95995.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/466/article-466-2108641.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
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