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، جلد ۷، شماره ۴، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Prediction of MicroRNAs bind to Toll-like Receptors Pathway in Chicken based on Bioinformatics Method |
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| چکیده انگلیسی مقاله |
Toll-like receptors (TLRs) recognize distinct pathogen-associated molecular patterns and play a critical role in innate immune responses. Activation of TLR-signaling pathways is required for hosts to eliminate invading pathogens. But excessive activation of these pathways may also disrupt immune homeostasis, leading to some diseases, therefore precise regulation of TLR-signaling pathways is important. Since miRNAs act as a class of small noncoding RNAs with gene regulatory functions, the regulation of TLR expression by miRNAs may one of the effective points for target TLRs. In this study, we predicted most of microRNAs bind to Toll-like receptors pathway in chicken based on bioinformatics method. Total genes involved in the TLR signaling pathway in chicken species were extracted from the KEGG database (Entry: gga04620) and analyzed based on bioinformatics software. We prediction 19 micro-RNA for the 18 target genes of TLR pathway that may provide important clues for identifying novel and attractive drug targets to inflammatory diseases. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Maryam Gholizade
Department of Animal Science, Agriculture and Natural Resources University of Khuzestan, Ahvaz, Iran.
| Jamal Fayazi
Department of Animal Science, Agriculture and Natural Resources University of Khuzestan, Ahvaz, Iran.
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1076-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ژنتیک |
| نوع مقاله منتشر شده |
پژوهشی |
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