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، جلد ۷، شماره ۴، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of Cell Growth Inhibition of Bifidobacterium bifidum cell-free supernatant Extract on 4T1 Tumor Cell Lineage |
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| چکیده انگلیسی مقاله |
Background: Cancer is amongst the leading reasons of death in all parts of the world. Breast cancer is also responsible for the largest number of deaths among women population. Several studies confirmed that Bifidobacterium bifidum as a probiotic meaningfully inhibited breast cancer development. The present study aimed to investigate the effect of B. bifidum supernatant on the cell growth inhibition of the breast cancer 4T1 cell line, in vitro. Materials and methods: The present experimental work was conducted at Mazandaran University of Medical Sciences (MAZUMS), Sari, Iran. B. bifidum was cultured in the MRS broth at 37°C for 72 hours anaerobically and the B. bifidum supernatant (BS) was prepared by the freezing-thawing procedure. The cell growth inhibition of the probiotic strain was assessed using the MTT assay through breast cancer (4T1) cell line. Results: The results showed that the supernatant extracted from B.bifidum strain had good antiproliferative effects against 4T1 cancer cell line, compared to control group. The inhibitory effects growing with increased time. Conclusion: B. bifidum supernatant could be considered as a as potential probiotic candidates in the treatment of breast cancer. However, further in vitro/in vivo studies are required to complement our initial findings. |
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| کلیدواژه‌های انگلیسی مقاله |
Breast cancer, Bifidobacterium bifidum, 4T1 cell line, MTT |
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| نویسندگان مقاله |
| Parisima Karami
Department of Microbiology and virology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Saeid Abediankenari
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Mehrdad Gholami
Department of Microbiology and virology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Mohammad Ahanjan
Department of Microbiology and virology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1062-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
باکتری شناسی پزشکی |
| نوع مقاله منتشر شده |
پژوهشی |
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