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، جلد ۷، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of IL-2 and IL-7 expression in patients with prostate cancer |
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| چکیده انگلیسی مقاله |
Background: Prostate cancer is a biologically heterogeneous disease which has become the fifth leading cause of cancer-related deaths in men worldwide. Interleukins (ILs) display required inflammation moderator. IL-2 and IL-7 play significant roles in regulating cancer-immune system interactions. So, the purpose of this investigation was to evaluate the expression level of IL-2 and IL-7 in prostate cancer patients and healthy subjects. Materials and methods: In this case-control study, expression of IL-2 and IL-7 was examined in peripheral blood of 40 prostate cancer patients and 40 healthy subjects by reverse transcription quantitative real-time polymerase chain reaction. Results: Our findings showed that IL-7 has highly elevated expression in patients with prostate cancer compared to healthy subjects (p-value = 0.0001). In contrast, no significant difference was observed in the expression of the IL-2 between the two study groups (p-value = 0.12). Conclusions: Based on the results, IL-7 may be used as a prospective biomarker or as a molecular target in designing new prostate cancer control strategies. However, the findings of this investigation revealed no association between IL-2 expression and prostate cancer. Nevertheless, more studies should be included to appraise the exact relevance of this gene to prostate cancer. |
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| کلیدواژههای انگلیسی مقاله |
Interleukin, IL-2, IL-7, Prostate cancer. |
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| نویسندگان مقاله |
| Faezeh Namazi
Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran
| Nasrin Hadi
Medical Genetics Research Center of Genome, Mohtasham St., Isfahan, Iran.
| Fatemeh Parnian
Medical Biotechnology, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
| Mansour Moghimi
Associate Professor of Clinical and Surgical pathology, Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1098-3&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ژنتیک |
| نوع مقاله منتشر شده |
پژوهشی |
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