|
|
، جلد ۵، شماره ۳، صفحات ۵-۱۰
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Blimp-1 Expression as an Exhaustion Transcription Factor in Chronic Lymphocytic Leukemia |
|
| چکیده انگلیسی مقاله |
Background: PPreviously, it was shown that exhausted CD4+ and CD8+ T cells in chronic lymphocytic leukemia (CLL) co-express the two immune-inhibitory receptors, Tim-3 and PD-1. Present study investigated the expression of Blimp-1, a transcription factor involved in T cell exhaustion, in patients with CLL. Materials and Methods: Peripheral blood mononuclear cells were collected from 25 untreated CLL patients and 15 sex- and age-matched normal subjects. CLL patients were clinically classified according to the Rai staging system. The relative expression of Blimp-1 mRNA was determined by quantitative Real Time Polymerase Chain Reaction (qRT-PCR) after normalization with β-actin. Results: Expression of Blimp-1 mRNA was much higher in CLL patients than in normal controls (p=0.001). Moreover, Blimp-1 was more expressed in patients with advanced clinical stages of CLL compared to those with early stages of the disease (p=0.01). Interestingly, the Blimp-1 expression was correlated with the frequencies of exhausted Tim-3+/PD-1+/CD4+ and Tim-3+/PD-1+/CD8+ T cells in CLL patients. Conclusion: Our results highlight the role of Blimp-1 transcription factor in T cell exhaustion of CLL. |
|
| کلیدواژه‌های انگلیسی مقاله |
Exhausted T cell, Blimp-1, Chronic Lymphocytic Leukemia |
|
| نویسندگان مقاله |
| Saeid Taghiloo
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Esmaeil Allahmoradi
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Mohsen Tehrani
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Ghasem Janbabaei
Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran
| Ramin Shekarriz
Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran
| Hossein Asgarian-Omran
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
|
|
| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-917-1&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2735/article-2735-2201176.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ایمونولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|