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، جلد ۳، شماره ۱، صفحات ۱۸-۲۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Identification and prioritization genes related to Hypercholesterolemia QTLs using gene ontology and protein interaction networks |
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| چکیده انگلیسی مقاله |
Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitative trait that is controlled by interactions among several quantitative trait loci. Many biological data is presented in the context of biological networks and evaluation of biological networks is considered as the essential key to understanding complex biological systems. In this research, we used combination of information about quantitative trait loci of hypercholesterolemia with information of gene ontology and protein–protein interaction network for identification of genes associated with hypercholesterolemia. For this disease, we introduced 16 new genes which were in quantitative trait loci regions and were associated with the hypercholesterolemia disease in terms of gene ontology characteristics. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Ali Kazemipour
Institute of Biochemistry and Biophysics, University of Tehran
| Bahram Goliaei
Institute of Biochemistry and Biophysics, University of Tehran
| Hamid Pezeshk
University of Tehran
| Behjat Kalantari khandani
Kerman University of Medical Sciences
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-698-1&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2735/article-2735-2201255.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ژنتیک |
| نوع مقاله منتشر شده |
پژوهشی |
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