|
|
، جلد ۲، شماره ۴، صفحات ۳-۱۱
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Myeloproliferative disorders and its associated mutations |
|
| چکیده انگلیسی مقاله |
Myeloproliferative Neoplasm (MPN) are a clonal disorder in hematopoietic stem cells (HSC). MPN is categorized to 8 subclasses, including chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocytopenia (ET), primary myelofibrosis (PMF), systematic mastositosis (SM), chronic eosinophilic leukemia (CEL), chronic neutrophilic leukemia (CNL), and unclassified myelofibrosis disorders (UMPN). It usually occurs in 5th to 7th decade of life. However, CNL and ET have been observed in children. A lot of mutations have been identified in these disorders that Jak2V617F is the most important mutation. Moreover, several somatic mutations other than JAK2V617F in MPN patients have been reported. Such mutations include MPL, TET2, ASXL1, IDH1, IDH2, CBL, LNK, IKZF, and EZH2 from precursor stem cells. The role of mutations mentioned is not clear in pathogenesis of this disease. Hence, in this study, mutations in different stages of myeloproliferative disorders have been reviewed. |
|
| کلیدواژه‌های انگلیسی مقاله |
MPN, Hematopoietic stem cells, Mutation |
|
| نویسندگان مقاله |
| Kaveh Tari
Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
| Reza Yarahmadi
Department of Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran
| Amir Tabatabaei
Department of Laboratory Sciences, School of Paramedical Sciences, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran
| Fakhredin Saba
Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
| Saeid Abroun
Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
| Amir Atashi
Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
| Masoud Soleimani
Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
|
|
| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-678-1&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2735/article-2735-2201260.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
هماتولوژی و آنکولوژی |
| نوع مقاله منتشر شده |
review |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|