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، جلد ۱، شماره ۳، صفحات ۲۹-۳۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of Teucrium polium leaf extracts on AMPK level in Isolated Rat Pancreases |
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| چکیده انگلیسی مقاله |
Background: The purpose of this study is to evaluate effects of Teucrium polium (TP) leaf extracts on adenosine monophosphate activated protein kinase (AMPK) level in isolated pancreases. Materials and Methods: In this experimental study, two groups of rats were used as a control group, and diabetic group. In the end of experimental period the animals were sacrificed then pancreas were removed, then isolated rat pancreas was cultured in buffer with or without TP leaf extracts. Measuring the sample glucose level was carried out by spectrophotometric method ( Jenway ,Model 6505 ,UK, Pars Azmmon Co. ,Tehran, IRAN) . Insulin level was assayed by an enzyme immunoassay ELISA kit specific for rats made by Mercodia Rat insulin ELISA ( 10-1250-01,Mercodia AB, Uppsala, Sweden). The adenosine monophosphate activated protein kinase level was determined by ELISA assay method using a rat phosphorylated AMPK ELISA kit ( CSB-E11337r, Cusabio Biotech Co .,LTD). Results: The results indicate that addition of TP leaf extract significantly increased AMPK level and insulin content compared to untreated group (p< 0.05). Conclusion: These results support the potential of TP leaf extract as a therapeutic modality for diabetes. However, further studies will be necessary to confirm this potential. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Durdi Qujeq
Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Ganjafrooze Avenue, Babol, Iran
| Mohsen Tatar
Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
| Farideh Feizi
Department of Anatomical Sciences, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
| Hadi Parsian
Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. 2Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
| Sohrab Halalkhor
Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-609-1&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2735/article-2735-2201291.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
شیمی دارویی |
| نوع مقاله منتشر شده |
پژوهشی |
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