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Anatomical Sciences Journal، جلد ۸، شماره ۳۰، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Expression of Gsk-3β And β-Catenin Proteins in the PMSG Stimulated Rat Ovary |
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| چکیده انگلیسی مقاله |
Purpose: The ovary is an example of a developing tissue in which developmental prosses occur throughout reproductive life. We investigate the expression of GSK-3β and β-catenin- Wnt pathway molecules- in the rat ovary during follicular development. Materials and Methods: To induce follicular growth and development, 23 days old immature female rats were injected with 10 IU of PMSG. Forty and forty-eight hours after stimulation with PMSG, the sera was collected for hormone assay, and the ovary were dissected and prepared for immunohistochemistry (IHC( and western blot(WB). Results: Our IHC and WB analysis showed that the expression of pGSK-3β and active β-catenin was increased in PMSG primed rats in compared to those of intact groups. However, the total GSK-3β and β-catenin proteins remain unchanged. Conclusion: The results indicate this idea that gonadotropin (PMSG), stabilized β-catenin in GSK-3β independent manner in the rat ovary during the follicular development. |
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| کلیدواژههای انگلیسی مقاله |
Gsk-3β, Β-Catenin, Ovarian Follicular Development, Rat |
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| نویسندگان مقاله |
| Fahimeh Mirakhouri
| Bahman Zeynali
| Azita Parvaneh Tafreshi
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| نشانی اینترنتی |
http://anatomyjournal.ir/browse.php?a_code=A-10-304-197&slc_lang=fa&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
Morphometry |
| نوع مقاله منتشر شده |
Original |
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