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Anatomical Sciences Journal، جلد ۴، شماره ۳، صفحات ۲۲۵-۲۳۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
The Study of Quercetin Effects on Behavioral and Nigrostriatal Tissue in the Experimental Model of Parkinson in Adult Rat |
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| چکیده انگلیسی مقاله |
Purpose: The aim of this study is investigating the effect of quercetin on behavioral and nigrostriatal tissue in the experimental model of Parkinson in adult rat. Materials and Methods: In this study we used 80 male rats from Wistar spring with body weight of 200-250 g. In order to make parkinson model, 6-OHDA (12.5 mg/kg) was injected intrastriatal unilaterally using stereotaxic method. Lesion rats were pretreated intraperitoneally with quercetin (20 mg/kg) one hour before surgery and once a day with 10 & 20 mg/kg doses up to one month after surgery. Rotational behaviore of apomorphine-induced postlesion was measured during the fifth week after surgery considered as treatment efficiency indicator. SNC cells were studied with nissle staning method. Results: Behavioral tests in the fifth week revealed that Apomorphine caused evident contralateral rotation in lesion group (P< 0.001) and very low rotation in treatment group (P< 0.01) comparing with sham group. Treatment group showed decrease in numbers of rotation (P< 0.01) comparing with lesion group. Treatment groups with 10 and 20 mg/kg Quercetin did not show significant differences statistically. The number of SNC neurons in left side showed significant reduction in lesion group (P< 0.001) and treatment groups (P< 0.01) comparing with right side, but did not show significant changes in sham group. Conclusion: Behavioral and structural results indicated short-term intra-peritoneal administration of quercetin is effective as an antioxidant in treatment of early PD and may enhance the survival of nigral dopaminergic neurons. |
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| کلیدواژههای انگلیسی مقاله |
Parkinson&apos,s disease, Antioxidant, 6-Ohda, Quercetin |
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| نویسندگان مقاله |
| Mahdi Mahdi Zadeh
Anatomy Departmen, Iran University Of Medical Sciences, Tehran, Iran.
| Roya Arian Poor
| Mohammad Taghi Joughataei
| Mehrdad Roughani
| Maliheh Noubakht
| Hamid Reza Asgari
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| نشانی اینترنتی |
http://anatomyjournal.ir/browse.php?a_code=A-10-304-143&slc_lang=fa&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
Morphometry |
| نوع مقاله منتشر شده |
Original |
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