|
|
Auditory and Vestibular Research، جلد ۳۱، شماره ۱، صفحات ۴۵-۵۲
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژههای فارسی مقاله |
|
|
| عنوان انگلیسی |
Different Types of Environmental Stressors Could Have Disruptive or Constructive Effects on Vestibular Compensation |
|
| چکیده انگلیسی مقاله |
Background and Aim: Stress could play either helpful or harmful roles in vestibular compensation, the process of recovery after vestibular system lesions. Herein, we examined the effect of two stressor types on vestibular compensation: chronic anxiety disorder induced by early maternal separation (MS), and caloric restriction by an intermittent fasting (IF) diet. Methods: Male Wistar rats (n=56) received maternal separation (the MS group), intermittent fasting (IF group), unilateral vestibular deafferentation (UVD group), or a mixture of these interventions (UVD+IF, UVD+MS, and UVD+IF+MS). All the groups were compared with control animals. The animals’ balance, motor coordination, anxiety, locomotor activity, and serum cortisol levels were evaluated by rotarod, open field, and enzyme-linked immunosorbent assay methods, respectively. The data were compared with those of the healthy control (HC) group. Results: The UVD animals did not show a significant change in the time on the rod, except for the IF+UVD group (p=0.04). There was no significant difference between the experimental groups on the open field indices, except for the MS+IF+UVD group which traveled a significantly less total distance (p=0.02). Serum cortisol levels were significantly higher than HCs for all the groups except for the sham saline and IF+UVD group (p< 0.05). Conclusion: IF seems to promote compensation after UVD, while MS may disrupt it. However, IF loses its beneficial outcomes if the animal has received another source of stress, i.e. MS. |
|
| کلیدواژههای انگلیسی مقاله |
|
|
| نویسندگان مقاله |
| Sara Sardari
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran AND Religious and Medicine Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
| Majid Asadi-Shekaari
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran AND Religious and Medicine Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
| Mohammad Khaksari
Department of Physiology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
| Iraj Aghaei
Neuroscience Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran
| Fateme Delavari
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
| Zohre Vaziri
Centre de Recherche CERVO, Department de Psychiatrie et de Neurosciences, Universite Laval, Quebec, Canada
|
|
| نشانی اینترنتی |
https://avr.tums.ac.ir/index.php/avr/article/view/955 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
|
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|