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Basic and Clinical Neuroscience، جلد ۱۳، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Investigating the Cocaine-induced Reduction of Potassium Current on the Generation of Action Potentials Using a Computational Model |
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| چکیده انگلیسی مقاله |
Introduction: Drugs of abuse, including cocaine, affect different brain regions and lead to pathological memories. These abnormal memories may occur due to the changes in synaptic transmissions or variations in synaptic properties of neurons. It has been shown that cocaine inhibits delayed rectifying potassium currents in affected regions of the brain and can have a role in the formation of pathological memories. Purpose: This study investigates how the change in the conductance of delayed rectifying potassium channels can affect the produced action potentials using a computational model. Methods: We present a computational model with different channels and receptors, including sodium, potassium, calcium, NMDARs, and AMPARs, which can produce burst-type action potentials. In the simulations, by changing the delayed rectifying potassium conductance bifurcation diagram is calculated. Conclusion: Results show that for a specific range of potassium conductance, a chaotic regime emerges in produced action potentials. These chaotic oscillations may play a role in inducing abnormal memories. |
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| کلیدواژه‌های انگلیسی مقاله |
Addiction, Cocaine, Delayed-rectifier potassium current, Computational model, Chaos |
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| نویسندگان مقاله |
| Hadi Borjkhani
School of ECE, College of Engineering, University of Tehran, Tehran, Iran.
| Mehdi Borjkhani
Faculty of Electrical engineering, Urmia University of Technology, Urmia, Iran.
| Morteza A. Sharif
Faculty of Electrical engineering, Urmia University of Technology, Urmia, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-1150-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Computational Neuroscience |
| نوع مقاله منتشر شده |
Original |
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