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Basic and Clinical Neuroscience، جلد ۱۲، شماره ۳، صفحات ۳۰۹-۳۱۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker |
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| چکیده انگلیسی مقاله |
Introduction: Multiple Sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As Myelin Basic Protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva as a suitable biomarker for detecting MS. Methods: A case-control study was performed in 29 healthy women and 32 definitive relapsing-remitting MS patients hospitalized in Imam Reza hospital, Tehran, Iran. MBP level was assayed in serum and stimulated and unstimulated whole saliva. Results: MBP was expressed at a lower level in serum and stimulated saliva of MS patients compared to the control group. The serum MBP level had a considerable correlation with its stimulated saliva level. The receiver operating characteristic analysis showed significant diagnostic ability for MBP to discriminate MS patients with serum and stimulated saliva from controls. Conclusion: Serum and saliva level of MBP is lower in MS, so it may be considered a potential biomarker in MS. |
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| کلیدواژههای انگلیسی مقاله |
Multiple sclerosis, Myelin Basic Protein, Saliva, Serum |
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| نویسندگان مقاله |
| Mohammad Hossein Mirzaii-Dizgah
Student Research Committee, School of Dentistry, AJA University of Medical Sciences, Tehran, Iran.
| Mohammad Reza Mirzaii-Dizgah
Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
| Iraj Mirzaii-Dizgah
Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-950-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
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