| چکیده انگلیسی مقاله |
Introduction: Vitamin D may affect the modulation of signaling pathways in the central nervous system. We aimed to evaluate the effect of high-dose vitamin D supplementation on neuropsychological functions in female adolescents. Methods: We studied the effects of 9 weeks of vitamin D supplementation (50000 IU vitamin D3 [cholecalciferol]/week) on cognitive abilities and sleep disorders in 940 adolescent girls. Results: Oral vitamin D supplementation improved cognitive abilities, including memory, inhibitory control, selective attention, decision making, planning, sustained attention, and cognitive flexibility in healthy adolescent girls (P< 0.001). The prevalence of subjects with insomnia after intervention fell from 15.0% to 11.3%. Similar results were also found for the prevalence of sleepiness (15.6% reduced to 14.7%), or cases with both insomnia and sleepiness (8.0% reduced to 6.1%; P< 0.05). Conclusion: High dose of vitamin D can improve cognitive abilities and alleviate insomnia and daytime sleepiness in adolescent girls. Further investigations are required on different population groups (age and gender) to determine the sustainability of these effects. The value of vitamin D therapy in other neurological disorders would also be of research interest. |
| نویسندگان مقاله |
| Afsane Bahrami
Cellular and Molecular Research Center, School of Medicine, Birjand University of Medical Sciences, Bijand, Iran.
| Fariborz Rezaeitalab
Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Seyed Kazem Farahmand
Department of Traditional Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Zahra Mazloum Khorasani
Endocrine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Seyed Mostafa Arabi
Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Hamidreza Bahrami-Taghanaki
Chinese and Complementary Medicine Research Center, School of Traditional and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Gordon A. Ferns
Division of Medical Education, School of Brighton & Sussex Medical, University of Brighton and the University of Sussex, Falmer, Brighton, Sussex, UK.
| Majid Ghayour-Mobarhan
Metabolic Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
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