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Basic and Clinical Neuroscience، جلد ۱۲، شماره ۳، صفحات ۳۷۳-۳۸۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
The Effect of Resistance Training and Berberine Chloride on the Apoptosis-related Unfolded Protein Response Signaling Pathway in the Hippocampus of Diazinon-poisoned Rats |
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| چکیده انگلیسی مقاله |
Introduction: Diazinon is one of the most widely-used organophosphate pesticides in the world. This toxin enters the body in various ways and induces oxidative stress in various tissues. It has been proved that activation of Unfolded Protein Response (UPR) under oxidative stress is a steady mechanism for maintaining cell function and survival. Therefore, the present study aimed to review the effect of Resistance Training (RT) and Berberine Chloride (BC) on the apoptosis-related UPR signaling pathway in the hippocampus of diazinon-poisoned rats. Methods: In this experimental study, 40 male Wistar rats weighing 250 ±50 g were randomly divided into eight groups of five rats of 1) diazinon + 2 mg/kg BC + RT, 2) diazinon + 15 mg/kg BC + RT, 3) diazinon, 4) diazinon + RT, 5) diazinon + 2 mg/kg BC, 6) diazinon + 15 mg/ kg BC, 7) healthy control, and 8) sham. The groups were treated for 5 weeks. At the end of the fifth week, ATF-4, ATF-6, and CHOP gene expression in hippocampus tissue were measured by quantitative real-time RT-PCR. Results: Diazinon significantly increased the expression of ATF-4, ATF-6, and CHOP in the hippocampus tissue of rats. Administrating 15 mg/kg BC with RT significantly decreased these genes, indicating a decrease in the rate of apoptosis in the hippocampus. Conclusion: This study showed that RT and BC have a protective effect against diazinon-induced toxicity in the hippocampus. |
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| کلیدواژههای انگلیسی مقاله |
Berberine chloride, Diazinon, Resistance training, Activating Transcription Factor 4 (ATF-4), Activating Transcription Factor 6 (ATF-6), CHOP |
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| نویسندگان مقاله |
| Ali Esfandiarifar
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
| Mohammad Ali Azarbayjani
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
| Maghsood Peeri
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
| Seyed Behnamedin Jameie
Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2250-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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