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Pharmaceutical and Biomedical Research، جلد ۷، شماره ۱، صفحات ۴۷-۵۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Assessment of Anticonvulsant Activities of Petroleum Ether Extract of Anacyclus pyrethrum Roots on Experimental Rats |
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| چکیده انگلیسی مقاله |
Background: Epilepsy is one of the most common neurological conditions and a significant cause of morbidity and mortality. Objectives: The present study aimed to evaluate the anticonvulsant activity of the petroleum ether extract of the root of Anacyclus pyrethrum on pentylenetetrazole (PTZ)-induced seizure model in Wistar rats. Methods: The composition of the petroleum ether extract of A. pyrethrum was first analyzed using gas chromatography-mass spectrometry (GC-MS). Subsequently, the anticonvulsant activities of these extracts (70 and 140 mg/kg, intraperitoneal injection) were evaluated on PTZ-induced seizures in rats. The protection rate against induced seizures, latency, and duration of seizures, as well as neurological symptoms, were assessed and compared to those protected by phenobarbital. Results: GC/MS analysis of the petroleum ether extract showed that the main components were octadecadienoic acid, hexadecanoic acid, diheptylcyclopropene, naphthalene, and methyl stearate. The extract (70 and 140 mg/kg) was found to provide significant protection against PTZ-induced seizures. Moreover, compared to the negative control, the extracts increased the latency of induced-convulsion and reduced the duration of epilepsy. Interestingly, the extracts showed a reduction in neurological symptoms and the severity of seizures compared to the negative control. All of these outcomes manifested in a dose-dependent manner. Conclusion: The petroleum ether extract of A. pyrethrum may produce anticonvulsant effects by reducing the duration of seizures and delaying the latency of seizures induced by PTZ. |
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| کلیدواژههای انگلیسی مقاله |
Anacyclus pyrethrum, Gas chromatography-mass spectrometry (GC/MS), Pentylenetetrazole, Anticonvulsant activity |
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| نویسندگان مقاله |
| Bashir A. Yousef
Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
| Zeinab Awad
Department of Pharmacology, Faculty of Pharmacy, Sudan International University, Khartoum, Sudan.
| Somaya Adam
Department of Pharmacology, Faculty of Pharmacy, Sudan International University, Khartoum, Sudan.
| Setalbanat Abdelgadir
Department of Pharmacology, Faculty of Pharmacy, Sudan International University, Khartoum, Sudan.
| Ansam Mergani
Department of Pharmacology, Faculty of Pharmacy, Sudan International University, Khartoum, Sudan.
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| نشانی اینترنتی |
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-863-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فارماکولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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