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Basic and Clinical Neuroscience، جلد ۱۳، شماره ۵، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Effect of Hydro-Alcoholic Root Extract of Delphinium Denudatum Wall on Mecamylamine-Precipitated Nicotine-Withdrawal And Corticosterone Levels in Rats |
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| چکیده انگلیسی مقاله |
This study evaluates the effects of hydro-alcoholic root extract of Delphinium denudatum Wall (Jadwar, family; Ranunculaceae) for its ability to attenuate the nicotine-withdrawal in nicotine-dependent rats. The physical dependence on nicotine was induced in male adult Wistar albino rats (175-250 g) by subcutaneous implantation of Alzet mini osmotic pumps which supplied nicotine at 9.0mg/kg/day, while control rats received saline via osmotic pumps. For seven days four separate test doses of hydro-alcoholic root extract of Delphinium denudatum Wall (200, 400, 800, 1600 mg/kg) were given orally. On the 7th day, a mecamylamine injection (1 mg/kg, s.c.) was given to precipitate nicotine-withdrawal. The global Gellert's–Holtzman rating scale was used to rate somatic signs of withdrawal for 15 minutes, followed by a measurement of motor activity. Drug Bupropion was used as a positive control. Serum levels of nicotine (cotinine) and corticosterone were done by ELISA. In nicotine-dependent rats, oral administration of Delphinium denudatum Wall root extract suppressed the hyper-locomotion and decreased the corticosterone levels at all dosages. Higher doses (800 and 1600 mg/kg) of extract, significantly attenuated nicotine withdrawal whereas, lower doses (200 and 400 mg/kg) had no significant effect. These results suggest that hydro-alcoholic root extract of Delphinium denudatum Wall may prove to be a potential therapeutic agent to attenuate nicotine dependence and facilitate tobacco smoking cessation. |
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| کلیدواژههای انگلیسی مقاله |
Delphinium denudatum Wall, Nicotine, Hydro-alcoholic, Withdrawal, Bupropion, Mecamylamine |
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| نویسندگان مقاله |
| Raka Jain
National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
| Rahul Raghav
National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
| Mohd. Waseem
National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
| Azhar Jabin
Faculty of Unani Medicine, Jamia Hamdard University, New Delhi, India.
| Sonali Jhanjee
National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2559-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Behavioral Neuroscience |
| نوع مقاله منتشر شده |
Original |
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