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Basic and Clinical Neuroscience، جلد ۱۳، شماره ۵، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Retinal Ganglion Cell Complex In Alzheimer`S Disease: Comparison Of Ganglion Cell Complex And Central Macular Thickness In Alzheimer’s Disease And Healthy Subjects Using Spectral Domain-Optical Coherence Tomography (SD-OCT) |
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| چکیده انگلیسی مقاله |
Introduction: Alzheimer's disease (AD) is the commonest form of dementia worldwide. The modalities to diagnose AD are generally expensive and limited. Both CNS and Retina are derived from cranial neural crest, so the changes in retinal layers may reflect the changes in CNS tissue. Optical Coherence Tomography (OCT) machine can show the delicate retinal layers and is widely used in retinal disorders. The purpose of this study is to find a new biomarker to help clinicians diagnose AD by the means of retinal OCT examination. Methods: After considering the inclusion and exclusion criteria, 25 patients with mild and moderate AD and 25 normal matched subjects were enrolled in the study. OCT was done for all eyes. Central Macular thickness (CMT) and Ganglion Cell Complex (GCC) thickness were calculated. Groups were compared using SPSS 22 software. Results: Both GCC thickness and CMT were significantly decreased in patients with AD, compared to healthy age and sex matched subjects. Conclusion: Retinal changes, specifically CMT and GCC thickness, may reflect the AD process in brain. OCT may be considered as a non-invasive and inexpensive means to help diagnose the AD. |
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| کلیدواژههای انگلیسی مقاله |
Alzheimer`s disease, Optical Coherence Tomography, Ganglion Cell Complex, Central Macular Thickness |
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| نویسندگان مقاله |
| Zahra Farzinvash
Ophthalmology Department, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
| Marzie Abutorabi-Zarchi
Neurology Department, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
| Masoudreza Manaviat
Ophthalmology Department, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
| Habib Zare Mehrjerdi
Ophthalmology Department, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
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| نشانی اینترنتی |
http://bcn.iums.ac.ir/browse.php?a_code=A-10-2040-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Neuroscience |
| نوع مقاله منتشر شده |
Original |
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