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عنوان انگلیسی Difference in the Cytomegalovirus-related Clinical Laboratory Findings Between Patients With Bone Marrow and Kidney Transplantations
چکیده انگلیسی مقاله Background: Despite close monitoring of transplant patients, Cytomegalovirus (CMV) infection has remained one of the most critical problems in transplantation. This study investigates the relationship between CMV viral load and clinical laboratory findings in transplant recipients. Materials And Methods: A total of 34 transplant recipients comprising 15 Kidney Transplant (KT) recipients and 19 Bone Marrow Transplant (BMT) recipients admitted to the Imam Reza Hospital in Kermanshah Province, Iran, were enrolled in this study. The CMV viral load was quantified by the real-time PCR technique. Results: The CMV viral load in KT recipients was significantly higher than in BMT recipients (P=0.03), and there was a positive association between the level of virus and the level of cyclosporine in the blood of patients (r=0.51, P=0.02). Besides, CMV viral load was positively correlated with WBC (r=0.32, P=0.04), urea (r=0.47, P=0.002), creatinine (r=0.39, P=0.01), aspartate aminotransferase (r=0.33, P=0.04), and lactate dehydrogenase (r=0.4, P=0.01). Also, it was negatively associated with albumin (r=-0.61, P< 0.001), sodium (r=-0.4, P=0.01), and calcium levels (r=-0.46, P=0.003). There were also significant differences between KT and BMT recipients regarding the CMV-related clinical laboratory findings of urea (P=0.02), creatinine (P=0.001), uric acid (P=0.005), direct bilirubin (P=0.04), albumin (P=0.04), platelet (P< 0.001), and sodium (P=0.04) levels. Conclusion: Based on present data, we conclude that despite careful monitoring of patients, infection with CMV is still one of the most important problems associated with organ transplantation, which is directly related to many laboratory findings.
کلیدواژه‌های انگلیسی مقاله Cytomegalovirus, Bone marrow transplantation, Kidney transplantation, Viral load, Cyclosporine
نویسندگان مقاله | Misagh Rajabinejad
Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran


| Ramin Lotfi
Clinical Research Development Center, Tohid Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran


| Seyed Askar Roghani
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Elham Koolani
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Bijan Soleymani
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Alireza Rezaiemanesh
Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Zahra Mohamadi Kish
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Behrooz Halashi
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Ali Khorasanizadeh
Student Research Committee, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Zhila Shaveisizadeh
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Kamran Mansouri
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
نشانی اینترنتی http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1222-1&slc_lang=en&sid=1
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