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، جلد ۹، شماره ۲، صفحات ۱۳۹-۱۴۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Bioinformatics Evaluation of SPATA19 Gene Expression in Different Parts of Brain |
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| چکیده انگلیسی مقاله |
Background: Determining the expression pattern of testis genes in the brain is essential for understanding tissue functions and correlation or inter-correlation between testis and the brain. In this study, we examined spermatogenesis-associated 19 (SPATA19 gene) expression in 10 parts of the brain with bioinformatics analysis. Materials and Methods: The public dataset GSE46706, including 1231 samples originated from 134 Caucasian individuals, was downloaded from NCBI Gene Expression Omnibus (GEO). SPATA19 gene expression in the cerebellar cortex, frontal cortex, hippocampus, medulla, occipital cortex, putamen, substantia nigra, temporal cortex, thalamus, and white matter was examined against each other using R software and the t-test. Results: Out of 10 brain parts examined, the cerebellar cortex and white matter showed the highest expression, and the temporal cortex showed the lowest expression of the gene. So the cerebellar cortex had a 5.6% and 6.2% increase in gene expression relative to the putamen and temporal cortex with P values of 6.04e-13 and 2.15e-17, respectively. Also, the white matter had a 4% increase in gene expression over the temporal cortex with a P value of 1.89e-13. Conclusion: SPATA19 had more expression in the cerebellar cortex and white matter than other brain parts. These two parts make up the cerebellum. |
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| کلیدواژه‌های انگلیسی مقاله |
Bioinformatics, Brain, Testis, SPATA19, Gene Expression Omnibus (GEO) |
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| نویسندگان مقاله |
| Mahsa Zargar
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
| Sina Majidian
Department of Electrical Engineering, School of Electrical Engineering, Iran University of Science & Technology, Tehran, Iran.
| Mohammad Hossein Modarressi
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
| Sasan Shabani
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1115-3&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
بیولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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