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، جلد ۸، شماره ۴، صفحات ۱۵۳-۱۶۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Transcription Factor Assay of Peripheral Blood T cells in Different Groups of Rheumatoid Arthritis Patients |
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| چکیده انگلیسی مقاله |
Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and other tissues and organs of the body. Previous reports have demonstrated the imbalance of T helper (Th) subsets and Treg activity in the development, progression, and remission of RA. Here, we investigated the mRNA expression of four major transcription factors T-bet (Th1), GATA (Th2), RORc (Th17), and Foxp3 (Treg) in peripheral blood of different groups of RA patients. Materials and methods: In this case-control study, 60 patients with RA, including 20 newly diagnosed, 20 under treatment, and 20 in remission, as well as 20 patients with osteoarthritis, and 20 age- and the sex-matched healthy individual were enrolled. Diagnosis and classification of patients were done according to the American College of Rheumatology criteria. The relative mRNA expression of transcription factors, including T-bet, GATA, RORc, and Foxp3, was measured using qRT-PCR. Results: The relative expression of T-bet in RA patients was significantly increased in healthy controls (P = 0.002), while the relative expression of Foxp3 in RA patients was significantly decreased in healthy controls (P < 0.0001). There was no significant difference in the expression of GATA3 or RORc among RA patients, healthy controls, and osteoarthritis group. Conclusions: The results indicate the importance of Th1 and Treg cells in RA; however, the role of Th17 cells appear to be of little importance in these patients. It seems that Th2 cells do not interfere with RA development. |
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| کلیدواژه‌های انگلیسی مقاله |
Rheumatoid Arthritis, Osteoarthritis, T-bet, GATA3, FOXP3, RORc |
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| نویسندگان مقاله |
| Saeid Taghiloo
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Abolghasem Ajami
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Mohsen Tehrani
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Arezou Abbasi
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
| Reza Alizadeh-Navaei
Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran
| Mohsen Akhiani
Department of Rheumatology, Alborz Hospital, Alborz University of Medical Sciences, Karaj, Iran
| Alireza Salami
Department of Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
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| نشانی اینترنتی |
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-917-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ایمونولوژی |
| نوع مقاله منتشر شده |
پژوهشی |
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